Genotyping of the EIF1AY Gene in Iranian Patients with Non-Obstructive Azoospermia
نویسندگان
چکیده
منابع مشابه
Screening of two closed mutations in CFTR gene of Iranian infertile men with non-obstructive azoospermia
Background The genetic association between cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and male infertility due to congenital bilateral absence of vas deferens (CBAVD) is well established. Mutant CFTR, however may also be involved in the etiology of male infertility in non-CBAVD cases. The present study was conducted to estimate the frequency of ΔI507 and ΔF508 CFT...
متن کاملHIWI2 rs508485 Polymorphism Is Associated with Non-obstructive Azoospermia in Iranian Patients
Background: The PIWI-interacting RNA (piRNA) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. HIWI genes are critical for piRNA biogenesis and function. Therefore, polymorphisms in HIWI genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. The aim of the present study was to i...
متن کاملdeletion and testicular expression of daz (deleted in azoospermia) gene in patients with non-obstructive azoospermia
background: deletions of the daz (deleted in azoospermia) genes within the human y chromosome's azfc region are the most common cause of spermatogenesis failure. these deletions are usually assessed by analyses of genomic dna extracted from peripheral leukocytes. daz genes are expressed in male germ cells. in this prospective study, we investigated daz expression and deletion in 102 consecutiv...
متن کاملFrequency of CYP1A1 Gene Polymorphisms in Infertile Men with Non-obstructive Azoospermia
Background and Aims: The cytochrome P450 1A1 (CYP1A1) plays a curial role in phase I metabolism of polycyclic aromatic hydrocarbons to their ultimate biologically active intermediates that have potential reproductive toxicity in men. Reproductive functions in men may be impaired by many environmental, physiologic, and genetic factors. The majority of the environmental factors are xenobiotics. M...
متن کاملHigh prevalence of AZFb microdeletion in Iranian patients with idiopathic non-obstructive azoospermia.
BACKGROUND & OBJECTIVES Genetic factors contribute about 10 per cent of male infertility. Among these, genes in azoospermia factor (AZF) region including AZFa, AZFb, AZFc and AZFd on the long arm of Y chromosome are considered most important for spermatogenesis. Deletions in these regions are thought to be involved in some cases of male infertility associated with azoospermia or oligozoospermia...
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ژورنال
عنوان ژورنال: Current Urology
سال: 2019
ISSN: 1661-7649
DOI: 10.1159/000499295